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Discussion Macrophages have critical homeostatic functions that balance organ health, and disruption of tissue homeostasis can lead to disease

10.1371/journal.pone.0167671 63 LiC.LiQ.HongJ.ChenF.GuoC

Phosphorylation of H3Y99 is critical for polyubiquitination and subsequent proteolysis of excess histones, which can increase a cells sensitivity to DNA-damaging agents, cause genomic instability and induce apoptosis